Are you feeling overwhelmed and exhausted from the constant battle with anxiety? If so, you are not alone.

An estimated 40 million American adults suffer from an anxiety disorder every year.

Many people attempt to manage their symptoms through lifestyle changes, such as increasing physical activity or seeking counseling.

However, when those adjustments aren’t enough, over-the-counter medications can be a safe option to explore.*

This blog post will highlight the best over-the-counter anxiety medications available and provide information regarding how they work and what potential risks they may pose.

How We Choose

We hope you find the product that works great for you from the list below! Each product was independently selected by our editors.

Some may have been sent as samples for us to try out, but all opinions in this article are our own.

Oh, and FYI — EasyHealthHacks may collect a share of sales or other compensation from the links on this page if you decide to buy something (that's how we stay in business).

We hope you enjoy the extensive research we've done to find the top picks on Amazon so you don't have to!

NutriRise Organic Ashwagandha Root with Black Pepper Capsules

NutriRise Organic Ashwagandha Root with Black Pepper Capsules

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Why We Love It

NutriRise Organic Ashwagandha Root with Black Pepper Capsules is the best over-the-counter anxiety medication that provides an optimal concentration of withanolides, clinically proven to support natural stress management and hormonal balance.

This ayurvedic herb has been used for centuries for its superior benefits in reducing fatigue, optimizing mood and energy levels, and supporting a healthy thyroid.

It also serves as an all-natural vegan nootropic to improve memory, focus, and concentration and promote deeper restful sleep.

Best of all, NutriRise Organic Ashwagandha Root with Black Pepper Capsules is certified organic by UDAF and GMP certified with 3rd party testing, prescription medication, so you can trust that it’s pure and of the highest quality.

What You Should Know

  • NutriRise Organic Ashwagandha Root with Black Pepper Capsules are vegan, non-GMO, gluten-free, and do not contain magnesium stearate, dioxide, preservatives, soy, sugar, yeast, starch, or other GMO ingredients.
  • They should be taken as dietary supplements with good nutrition and a healthy lifestyle.
  • If you are pregnant, nursing, taking any medications, or have a medical condition, please consult your healthcare practitioner before use.

NaturaLife Labs Pure Organic Ashwagandha Powder and Root Extract

NaturaLife Labs Pure Organic Ashwagandha Powder and Root Extract

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Why We Love It

Organic Ashwagandha 2,100 mg is the perfect over-the-counter anxiety medication because it helps reduce stress and anxiety while providing immune and thyroid support.

Its vegan capsules are easy on your stomach and provide superior potency with 2100 mg per serving.

Best of all, it comes with a 100% satisfaction guarantee, so you can get your money back if you don't feel the results.

So if you're looking for an effective and natural way to reduce stress and anxiety, you owe it to yourself to try Naturalife Labs Organic Ashwagandha.

What You Should Know

  • Naturalife Labs Organic Ashwagandha is a natural Ayurveda stress relief product that provides superior potency with 2100 mg per serving and 100 vegan capsules.
  • It's made with pure organic ashwagandha powder root & ashwagandha root extract with black pepper extract to help maximize absorption.
  • This product is manufactured in an FDA-registered facility in accordance with Good Manufacturing Practices GMP.
  • Common side effects may include nausea, stomach upset, and diarrhea. Be sure to consult your healthcare practitioner before taking this product.

Natrol, 5-HTP Time Release Tablets, Maximum Strength

Natrol, 5-HTP Time Release Tablets, Maximum Strength

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Why We Love It

Natrol 5-HTP Time Release Tablets is the best over-the-counter anxiety medication, providing a drug-free way to reduce stress and anxiety.

Natrol's unique time-release formula helps to provide more consistent levels of serotonin throughout the day.

Moreover, its non-GMO formulation helps control appetite and promote a positive attitude.

Natrol is a trusted name in wellness, providing safe and effective supplements to enhance mood and overall health.

With the help of this supplement, you can take control of your mental health and start living life on your terms!

What You Should Know

  • Natrol 5-HTP Time Release Tablets, Maximum Strength, 200 mg, 60 Count is an all-natural supplement made with Griffonia Simplicifolia seed extract and other natural ingredients.
  • It should be taken in one capsule twice daily for maximum efficacy and can be taken in the morning or evening.
  • Please note that exposure to heat or sunlight may lead to melting/damage of the product.
  • This supplement is non-habit-forming and safe to use, making it an ideal solution for managing stress and anxiety.
  • So, give Natrol 5-HTP Time Release Tablets a try today! It’s the best over-the-counter anxiety medication to help you feel relaxed and in control.
  • Best of all, it’s drug-free, non-GMO, and manufactured by a reliable U.S. company that is trusted worldwide.

Happy Healthy Hippie Joy-Filled Mood Support Supplement

Happy Healthy Hippie Joy-Filled Mood Support Supplement

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Why We Love It

Happy Healthy Hippie Joy-Filled Mood Support is a natural, plant-based supplement designed to help you find your inner joy and combat stress.

Their formula features seven powerful adaptogenic herbs, including ashwagandha root powder and St. John’s Wort, works together to support relaxation, mental clarity, and mood.

Their capsules are 100% plant-based, non-GMO, vegan, and made with ingredients grown on farms worldwide.

Try them today and see how you can find zen in your day-to-day life.

What You Should Know

  • Happy Healthy Hippie Joy-Filled Mood Support is an all-natural, plant-based supplement to help you find your inner joy and combat stress.
  • Their formula features seven powerful adaptogenic herbs, including ashwagandha root powder and St. John’s Wort, which work together to support relaxation, mental health, professional clarity, and mood.

OLLY Ultra Strength Goodbye Stress Softgels

OLLY Ultra Strength Goodbye Stress Softgels

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Why We Love It

OLLY Goodbye Stress Ultra Softgels are an excellent choice for those looking to manage anxiety stress in a natural, fast-acting way.

The combination of Ashwagandha, Lemon Balm, and other ingredients helps promote relaxation without leaving you feeling exhausted or tired.

In addition, the small size of the soft gel makes it easy to take on the go, and the strawberry scent is a nice bonus.

Best of all, OLLY Goodbye Stress Ultra Softgels are made without artificial colors or preservatives — so you know exactly what you're getting in each capsule!

Whether you're looking for a quick fix to help calm your nerves during a stressful situation or an everyday supplement to promote relaxation, OLLY Goodbye Stress Ultra Softgels are an excellent choice.

With a 30-day supply in each bottle, you can rest assured that your stress levels will be kept in check for the long haul.

Take it from us - this is one of the best over-the-counter decrease anxiety symptoms medications available.

What You Should Know

  • OLLY Goodbye Stress Ultra Softgels are formulated to help you relax without sacrificing energy levels, so don’t expect any drowsiness after taking them.
  • However, it is important to note that if you have any underlying medical conditions or take other medications, please consult a doctor before adding these soft gels to your routine.
  • With that being said, these supplements are a great way to naturally manage your stress levels and help you stay calm and centered — no matter what the situation. Best of all, the convenient size makes them easy to take anywhere you go.
  • So if you’re looking for an over-the-counter anxiety medication that can provide relief without any unwanted side effects, give OLLY Goodbye Stress Ultra Softgels a try.

Boiron StressCalm for Relief of Stress, Anxiousness, Nervousness, Irritability, and Fatigue

Boiron StressCalm

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Why We Love It

When it comes to the best over-the-counter severe anxiety medication, Boiron StressCalm is a great choice.

It’s an all-natural remedies blend of plant-based active ingredients specifically formulated to reduce nervous tension and calm the mind and body.

We also love that it won’t cause drowsiness or interact with other medications or supplements, so you can feel safe using it.

Best of all, it’s recommended for everyone ages 12 and up! Give Boiron StressCalm a try today if you're looking for relief from occasional nervousness, irritability, hypersensitivity, and fatigue due to everyday stress.

What You Should Know

  • Boiron StressCalm comes in a 60-count bottle.
  • It should be taken twice daily with meals unless directed by your healthcare practitioner.
  • Each dose contains two tablets of the active ingredients listed on this page.
  • It is not intended to diagnose, treat, cure, or prevent any disease.
  • Consult your healthcare practitioner before using it if you have a medical condition or are taking any otc medications.
  • Keep this and all medicines out of reach of children.
  • Store at room temperature, away from direct sunlight.

Best Over-The-Counter Anxiety Medication FAQs


What is the Best Over-The-Counter Anxiety Medication?

The best over-the-counter treat anxiety medication depends on your particular needs and circumstances. 

Popular options include ashwagandha, chamomile, St. John’s wort, valerian root, lavender, passionflower, and ginseng.

What is the Best Over-The-Counter Anxiety Drug?

The best over-the-counter anxiety drugs reduce your symptoms while providing minimal side effects. 

Some of the most popular options are benzodiazepines and SSRIs (Selective Serotonin Reuptake Inhibitors).*

What is the Best Over-The-Counter Anxiety Supplement?

Some popular over-the-counter anxiety supplements include omega-3 fatty acids, magnesium, L-theanine, herbal supplements, and B vitamins. 

These supplements may help to reduce your symptoms while providing additional health benefits.

Which Best Over-The-Counter Anxiety Medication is Best for Panic Attacks?

A variety of over-the-counter medications may help treat panic attacks. 

Popular options include benzodiazepines, beta-blockers, and SSRIs. Speak with your doctor to determine which option is best for you.

Which Best Over-The-Counter Anxiety Medication is Best for Social Anxiety?

Kava, chamomile, and valerian root are popular options for treating social reduce anxiety. Speak with your doctor to determine which option is best for you.

What Best Over-The-Counter Anxiety Medication has the Least Side Effects?

Herbal remedies such as kava, chamomile, St. John’s wort, valerian root, lavender, passionflower, and ginseng are all associated with fewer side effects than other over-the-counter medications.*

Are Best Over-The-Counter Anxiety Medications Safe?

Most otc anxiety medications are generally considered safe and effective for treating anxiety. 

However, it is always best to speak with your doctor before taking any medication or supplement.

Are Best Over-The-Counter Anxiety Medications Effective?

Many individuals have found relief from their anxiety symptoms through over-the-counter prescription medications. 

However, ensuring you are taking the right medication for your particular needs is important.

What Best Over-The-Counter Anxiety Medication is Best for Generalized Anxiety Disorder (GAD)?

Kava, chamomile, St. John’s wort, valerian root, lavender, passionflower, and ginseng are all popular options for treating generalized anti-anxiety medications disorder. Speak with your doctor to determine which option is best for you.*

What Best Over-The-Counter Anxiety Medication has the Best Reviews?

Ashwagandha is one of the most popular over-the-counter medications for prescription anxiety medication and generally has positive reviews. 

It's important to ensure you take the right dosage and speak with your doctor before starting any medication.

Summing It All Up

Finding the right medication can be challenging for anyone with anxiety disorders.

If you are looking for an over-the-counter option, these are some of the best choices available.

Do your research and talk to your doctor to find your best option.

And remember, it is always important to follow the instructions on the label when taking any medication.

So there you have it! All that's left is to head over to Amazon and check out the brand you think is best for you - thanks for stopping by, and be sure to check out our other blog posts for more information on living a healthy life!


*The statements in this article have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure, or prevent any disease.